AI researcher · Machine learning engineer

McClain Thiel

I build production AI systems and research generative models, post-training, and evaluation. I'm also a PhD student in the Barnes Lab at UCL, where I apply these methods to biology.

01 / Experience

Research to production

I have worked across the AI lifecycle—from research and model development to enterprise deployment—within data infrastructure, foundation-model tooling, and healthcare.

Databricks

Principal Forward Deployed AI Engineer · Contract

Partner with enterprise teams to design and deliver full-stack agentic and generative-AI systems on the Databricks platform.

University College London

PhD Student · Barnes Lab · Systems Biology, part-time

Researching language-model post-training and reinforcement learning for biological sequence design.

Encode: AI for Science

AI for Science Fellow · Pillar VC, ARIA & DSIT

Selected for a fellowship supporting researchers applying frontier AI methods to ambitious scientific problems.

Fellowship project ↗

Snorkel AI

Senior Machine Learning Engineer

Led work across synthetic data, multimodal evaluation, and agentic data generation to improve task-specific performance of generative-AI systems.

WEALTHAWK

Founder & CTO

Built an AI-powered platform that identifies money-in-motion events for financial advisors. Acquired by Praxis Solutions.

Website ↗ Acquisition ↗

Tempus

Machine Learning Scientist · AI Solution Architect

Founding member of the generative-AI team. Led the company's first external LLM application, adopted by hundreds of pharma users, and developed secure clinical and genomic AI systems.

Nference

Data Scientist

Developed probabilistic models and clinical ML algorithms, while establishing shared MLOps and experiment-tracking practices.

UC Berkeley

B.A. Data Science · Minor in Bioengineering

Studied machine learning, statistics, and biological systems.

02 / Research

Publications

  1. 2026 ICML

    Effects of Structural Reward Shaping on Biophysical Properties in RL-Trained Plasmid Generators

    M. Thiel, A. Cunningham, C. P. Barnes

    Read paper ↗
  2. 2026 NeurIPS · In review

    PlasmidLM: A Promptable DNA Language Model via Verifiable-Reward Post-Training

    M. Thiel, C. P. Barnes

    Read preprint ↗
  3. 2025 In review

    Generative Design and Construction of Functional Plasmids with a DNA Language Model

    A. G. Cunningham, M. Thiel, L. Dekker, A. Shcherbakova, C. P. Barnes

    Read preprint ↗
  4. 2024 In review

    Designing Minimal E. coli Genomes Using Variational Autoencoders

    A. Shcherbakova, K. Sharma, M. Thiel, Y. Chen, C. S. Grierson, L. Marucci, D. Buchan, C. P. Barnes

    Read preprint ↗
  5. 2020 AGU Fall Meeting

    Crop Stage Estimation: A Multi-Satellite Historical Model and a Scalable Neural Network Forecaster

    N. Padmanabhan, A. Mahesh, A. Sripathy, A. Sujithkumar, A. Sun, C. Snell, M. Thiel, M. C. Evans

  6. 2020 Berkeley Institute for Data Science

    Generative Retraining of Rare Images for Computer Vision Systems

    P. Dykas, A. Liang, N. Hudait, W. Seward, M. Thiel

03 / Speaking & writing

Sharing the work

More notes →
04 / Contact

Consulting & collaboration

Practical AI expertise, from strategy through delivery.

Available for selected consulting, technical advisory work, and academic collaborations in generative AI, agentic systems, evaluation, and AI for science.

me [at] mcclainthiel.com